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目的 观察纳络酮、氟吗西尼、联合使用纳络酮和氟吗西尼治疗急性安定中毒的疗效和安全性。方法 将 45例安定中毒患者随机分为纳络酮组 ( 15例 )、氟吗西尼组 ( 15例 )和联合使用纳络酮、氟吗西尼治疗组 ( 15例 )。三组患者在常规治疗相同情况下 ,在相同时间内分别用纳络酮、氟吗西尼、纳络酮和氟吗西尼治疗 ,对三组患者 ,在治疗 0、5、15、60、90、180min进行镇静催眠评分 ,并作相关的常规及生化检查 ,持续监测患者生命体征、氧饱和度。结果 联合用药组的早期治疗有效率高于单独使用纳络酮组(P <0 .0 5 ) ,但观察终点治疗有效率无显著性差别。镇静催眠评分比较 ,使用氟吗西尼的两组在治疗过程中均要低于纳络酮组 ,联合使用两种药物治疗组更低 ,且有显著性差异。三组并发症比较无明显差异。结论 纳络酮 ,氟吗西尼都是治疗安定类药物中毒的有效药物 ,联合使用纳络酮和氟吗西尼是疗效体现更早、最终治疗结果更好。
Objective To observe the efficacy and safety of naloxone and flumazenil in combination with naloxone and flumazenil in the treatment of acute stable poisoning. Methods 45 patients with stable poisoning were randomly divided into naloxone group (n = 15), fluocinolide group (n = 15) and naloxone and flumazenil treatment group (n = 15). The three groups were treated with naloxone, flumazenil, naloxone and flumazenil at the same time under the same conditions as the conventional treatment. The three groups of patients were treated at 0, 5, 15, 60, 90,180min sedation hypnosis score, and for the relevant routine and biochemical tests, continuous monitoring of vital signs, oxygen saturation. Results The effective rate of early treatment in combination group was higher than that in naloxone alone group (P <0.05), but there was no significant difference between the two groups. Hypnosis and Hypnosis scores were significantly lower in the two groups treated with flumazenil than in the naloxone group, and the combination of the two drugs was lower and statistically significant. Complications of the three groups no significant difference. Conclusion Naloxone and flumazenil are both effective drugs for the treatment of diazepam. The combination of naloxone and flumazenil is earlier and the final treatment result is better.