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近10年来寄生虫病的化疗进展较快,发现了不少疗效高、耐受性好、疗程短、服用方便的抗虫新药。苯并咪唑类从咪唑类药物应用以来,陆续发现了新的衍生物如甲苯咪唑,氟苯咪唑和丙硫苯咪唑等,致使肠道线虫病的治疗大为改观(表1)。目前,国内外学者公认丙硫苯咪唑为苯并咪唑类药物中最好的驱虫药。本药系一跨纲广谱、高效驱虫最新药物。表2为推荐治疗方案。丙硫苯咪唑从胃肠道吸收,在肝脏内代谢成为具有杀虫活力的亚砜,然后渗出回到胃肠道内。其杀虫机理被认为选择性与不可逆性抑制成虫摄取葡萄糖,使自体内源性糖原耗竭和抑制延胡索酸还原酶,阻碍ATP产生,使虫体无法生存与生殖,最终死亡。我们用丙硫苯咪唑治疗实验性动物华支睾吸虫病,治疗后虫体经扫描电镜观察,发现虫体体表多处出现局灶
Parasitic diseases in the past 10 years the rapid progress of chemotherapy, found a lot of high efficacy, good tolerance, short course, easy to take new insect-resistant drugs. Benzimidazoles Since the application of imidazoles, new derivatives such as mebendazole, flubendazole and albendazole have been discovered one after another, resulting in a significant improvement in the treatment of intestinal nematode disease (Table 1). At present, domestic and foreign scholars recognized as the best anti-benzimidazole benzimidazole drugs de-worming drugs. The medicine is a cross-broad spectrum, highly efficient deworming latest drug. Table 2 is the recommended treatment. Propionibenzole is absorbed from the gastrointestinal tract and is metabolized in the liver to a biologically active sulfoxide, which is then exuded back into the gastrointestinal tract. Its insecticidal mechanism is considered selective and irreversible inhibition of adult glucose uptake, the autologous endogenous glycogen depletion and inhibition of fumarate reductase, hinder the production of ATP, the parasites can not survive and reproduce, and eventually die. We use propylthiophene imidazole treatment of experimental animals Clonorchiasis, after treatment of parasites observed by scanning electron microscopy and found that the body surface of the worm appeared in many places