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加锡果宁(edulinine)系从芸香科植物中分离出的一种生物碱。ip或ig加锡果宁对大鼠、小鼠最大电休克(MES)有明显的对抗作用,并能对抗谷氨酸钠、戊四唑和硫代氨基脲引起的惊厥,但对印防己毒素诱发的惊厥没有明显影响。小鼠利血干预处理后,加锡果宁抗MES的ED_(50)明显增加,表明加锡果宁具有较强的抗惊厥作用,其作用可能与中枢某些递质有关。
Edulinine is an alkaloid isolated from Rutaceae plants. ip or ig plus tin and cinnabar significantly antagonized the maximum electrical shock (MES) in rats and mice, and can antagonize the convulsions caused by sodium glutamate, pentylenetetrazole and thiosemicarbazone, Evoked convulsions did not have a significant effect. The effect of anti-convulsion was better than that of the control group (P <0.05). After pretreatment with lentivirus, the ED50 of anti-MES plus tinctin increased obviously.