Drug-induced Fatty Liver Disease: Pathogenesis and Treatment

来源 :临床与转化肝病杂志(英文版) | 被引量 : 0次 | 上传用户:liongliong537
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Metabolic dysfunction-associated fatty liver disease (com-monly known as MAFLD) impacts global health in epidemic proportions, and the resulting morbidity, mortality and eco-nomic burden is enormous. While much attention has been given to metabolic syndrome and obesity as offending fac-tors, a growing incidence of polypharmacy, especially in the elderly, has greatly increased the risk of drug-induced liver injury (DILI) in general, and drug-induced fatty liver dis-ease (DIFLD) in particular. This review focuses on the con-tribution of DIFLD to DILI in terms of epidemiology, patho-physiology, the most common drugs associated with DIFLD, and treatment strategies.
其他文献
Background and Aims: The overall survival (OS) of hepa-tocellular carcinoma (HCC) remains dismal. Bioinformatic analysis of transcriptome data could identify patients with poor OS and may facilitate clinical decision. This study aimed to develop a prognos
Background and Aims: Protein phosphatase 2A (PP2A) is associated with many cancers. This study aimed to clarify whether PPP2CA, which encodes the alpha isoform of the catalytic subunit of PP2A, plays a role in hepatocellular carcinoma (HCC) and to identif
Background and Aims: Fibroblast growth factor (FGF)19 has been implicated in the pathogenesis of murine hepa-tocellular carcinoma. Whether it plays a role in the devel-opment or course of human cholangiocarcinoma remains to be determined. The aim of this
Background and Aims: There are no comparative studies on the efficacy of hepatic resection (HR) and CyberKnife stereotactic body radiation therapy (CK-SBRT) plus tran-shepatic arterial chemotherapy embolization (TACE) in the treatment of large hepatocellu
Background and Aims: Spontaneous bacterial peritonitis (SBP) is one of the leading causes of death in patients with liver cirrhosis. We aimed to establish a prognostic model to evaluate the 1-year survival of cirrhosis patients after the first episode of
Background and Aims: The pathogenesis of liver fibrosis involves liver damage, inflammation, oxidative stress, and intestinal dysfunction. Indole-3-propionic acid (IPA) has been demonstrated to have antioxidant, anti-inflammatory and anticancer activities
Background and Aims: Endovascular implantation of io-dine-125 (125I) seeds strand combined with stent is an effec-tive method of treatment for portal vein tumor thrombosis. The aim of this study was to develop a novel endovascular brachytherapy stent (EVB
Background and Aims: Acute liver failure (ALF) is an inflam-matory process of acute liver cell injury. Mesenchymal stem cells (MSCs) are undifferentiated, primitive cells with anti-inflammatory, anti-apoptotic, and multi-directional differen-tiation abili
The diagnosis of metabolic-associated fatty liver disease is based on the detection of liver steatosis together with the presence of metabolic dysfunction. According to this new defi-nition, the diagnosis of metabolic-associated fatty liver disease is ind
Nonalcoholic fatty liver disease (NAFLD) affects about a quar-ter of the world\'s population and poses a major health and economic burden globally. Recently, there have been hasty attempts to rename NAFLD to metabolic-associated fatty liv-er disease (MA