【摘 要】
：
Background and Aims: Endovascular implantation of io-dine-125 (125I) seeds strand combined with stent is an effec-tive method of treatment for portal vein tumor thrombosis. The aim of this study was to develop a novel endovascular brachytherapy stent (EVB
【机 构】
：
Department of Interventional Radiology,Zhongshan Hospital,Fudan University,Shanghai,China;Shanghai I
论文部分内容阅读
Background and Aims: Endovascular implantation of io-dine-125 (125I) seeds strand combined with stent is an effec-tive method of treatment for portal vein tumor thrombosis. The aim of this study was to develop a novel endovascular brachytherapy stent (EVB-Stent) and to evaluate its feasi-bility of use. Methods: An EVB-Stent was implanted into the main portal vein (MPV) in a live porcine model via the percutaneous transhepatic route. Blood samples were col-lected and tested before and after operation, as well as before euthanasia. Single-photon emission computed to-mography (SPECT) combined with CT (SPECT/CT) scan were performed directly after operation and CT scan was performed 2 months after implantation. After the CT scan was performed, all animals were euthanized and histologi-cally examined. Results: The novel stent was successfully positioned in all six pigs. No deterioration of liver function was observed during the 2-month follow-up period. SPECT/CT revealed the uniform distribution of radiation around the seeds strand, and the hottest spot was near the center of the MPV. The patency of the stented MPV was confirmed using CT scans. The tissue-accumulated absorbed dose was 31,822.11 mGy at 10 mm transversely away from the mid-point of the 125I seeds strand, with a half-life of 59.4 days. Pathological examination results showed no significant at-rophy or inflammation of adjunct liver tissue, and no obvi-ous intima thickening or thrombosis were detected in the stented MPV. Conclusions: A liver porcine model was used to demonstrate that the transhepatic placement of a novel endovascular brachytherapy stent, EVB-Stent, is both tech-nically feasible and safe.
其他文献
Background and Aims: Screening for hepatopulmonary syndrome in cirrhotic patients is limited due to the need to perform contrast enhanced echocardiography (CEE) and arterial blood gas (ABG) analysis. We aimed to develop a simple and quick method to screen
Background and Aims: It is critical but challenging to predict the prognosis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). This study systematically summarized and evaluated the quality and performance of available clinical predi
Background and Aims: The expression of discoidin do-main receptor 1 (DDR1) is commonly up-regulated and undergoes collagen-induced ectodomain (N-terminal) shed-ding during the progression of liver fibrosis. This study aimed to evaluate the clinical utilit
Background and Aims: Currently, insufficient clinical data are available to address whether low-level viremia (LLV) ob-served during antiviral treatment will adversely affect the clinical outcome or whether treatment strategies should be altered if LLV oc
Background and Aims: The overall survival (OS) of hepa-tocellular carcinoma (HCC) remains dismal. Bioinformatic analysis of transcriptome data could identify patients with poor OS and may facilitate clinical decision. This study aimed to develop a prognos
Background and Aims: Protein phosphatase 2A (PP2A) is associated with many cancers. This study aimed to clarify whether PPP2CA, which encodes the alpha isoform of the catalytic subunit of PP2A, plays a role in hepatocellular carcinoma (HCC) and to identif
Background and Aims: Fibroblast growth factor (FGF)19 has been implicated in the pathogenesis of murine hepa-tocellular carcinoma. Whether it plays a role in the devel-opment or course of human cholangiocarcinoma remains to be determined. The aim of this
Background and Aims: There are no comparative studies on the efficacy of hepatic resection (HR) and CyberKnife stereotactic body radiation therapy (CK-SBRT) plus tran-shepatic arterial chemotherapy embolization (TACE) in the treatment of large hepatocellu
Background and Aims: Spontaneous bacterial peritonitis (SBP) is one of the leading causes of death in patients with liver cirrhosis. We aimed to establish a prognostic model to evaluate the 1-year survival of cirrhosis patients after the first episode of
Background and Aims: The pathogenesis of liver fibrosis involves liver damage, inflammation, oxidative stress, and intestinal dysfunction. Indole-3-propionic acid (IPA) has been demonstrated to have antioxidant, anti-inflammatory and anticancer activities