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目的探讨适合国人ＴＢＩ剂量及方法。方法回顾分析ＨＳＣＴ前ＴＢＩ预处理方案的毒性及对植入、生存的影响。结果ＴＢＩ毒性未见明显增多，１２例全部植入。ＡＢＭＴ ６例中复发死亡１例，１例出院后３个月死于感染；另４例目前仍无病存活已７～９年；６例ＡＬＬＯ－ＨＳＣＴ中４例仍无病存活。结论认为国人ＴＢＩ仍以总剂量７～８Ｇｙ，一天内分两次给药为宜。
Objective To investigate the dose and method of TBI for Chinese people. Methods We retrospectively analyzed the toxicity of TBI pretreatment regimen before HSCT and its influence on implantation and survival. Results There was no significant increase in TBI toxicity. All 12 cases were implanted. ABMT recurred in 1 patient in 1 case, 1 patient died of infection 3 months after discharge; 4 patients still survived disease free for 7 to 9 years; 4 patients in ALLO-HSCT still survived without disease. The conclusion is that the national TBI is still a total dose of 7 ~ 8Gy, two times a day is appropriate.