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一、骨骼系统短肢畸胎和无肢畸胎虽然像短肢和无肢这样的肢体异常认为是遗传性的,但是现在认为也能由环境致畸胎因素所引起。1961～1962两年中在西德短肢畸胎发生率的增高,引起了对患儿母亲历史的追查。结果发现许多患儿的母亲曾服用过thalidomide这种药。这是一种在当时广泛用于催眠和治疗恶心的新药。现在已经肯定这种药于妊娠早期使用时,能引起一种特有的畸形综合微。这包括有:长骨的缺无和大体结构的变形,肠管闭锁,和心脏异常。把本品给予妊娠的家兔,其后代也可产生类似的缺陷,这就排除了对本品能产生这
First, the skeletal system short limb teratogenic and limbless teratogenic Although limbs such as short limbs and limbs is considered to be genetic abnormalities, but now that can also be caused by environmental teratogenic factors. In 1961 ~ 1962 two years in West Germany, the incidence of short-limb teratogenic, causing the history of children’s mothers tracing. The results showed that many children’s mothers had taken thalidomide. It was a new drug that was widely used at the time to hypnotize and treat nausea. It has now been affirmed that this medicine causes early onset of early pregnancy and causes a specific deformity syndrome. These include the absence of long bones and general structural deformation, bowel atresia, and cardiac abnormalities. Give this product to pregnant rabbits, their offspring can also produce similar defects, which ruled out this product can produce this