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为探讨血清肿瘤坏死因子α（ＴＮＦα）在糖尿病及血管并发症中的作用，采用ＥＬＩＳＡ法对６８例糖尿病患者［非胰岛素依赖型糖尿病（ＮＩＤＤＭ）４８例、胰岛素依赖型糖尿病（ＩＤＤＭ）２０例］血清ＴＮＦα水平进行了检测。结果显示：糖尿病组、ＮＩＤＤＭ组、ＩＤＤＭ组血清ＴＮＦα水平显著高于正常对照组（Ｐ＜０．０１），合并血管并发症组升高更明显（Ｐ＜０．０１）。血清ＴＮＦα水平与血糖不相关；与病程、血清甘油三酯呈正相关；与血清白蛋白呈负相关。治疗后随着病情好转，ＴＮＦα呈下降趋势。提示：血清ＴＮＦα增加是长期高血糖的结果。ＴＮＦα参与糖尿病血管并发症的发生、发展。动态检测血清ＴＮＦα水平可作为临床观察糖尿病病情变化的客观指标。
To investigate the role of serum tumor necrosis factor α (TNFα) in the pathogenesis of diabetes mellitus and vascular complications, 68 patients with diabetes mellitus (non-insulin-dependent diabetes mellitus (NIDDM) 48 and insulin-dependent diabetes mellitus (IDDM) 20) Serum TNFα levels were tested. The results showed that the levels of TNFα in diabetic group, NIDDM group and IDDM group were significantly higher than those in normal control group (P <0.01), and those in combined vascular complication group were more obvious (P <0.01). Serum TNFα level was not related to blood glucose; with course of disease, serum triglyceride was positively correlated; and serum albumin was negatively correlated. As the condition improved after treatment, TNFα showed a downward trend. Tip: Increased serum TNFα is the result of long-term hyperglycemia. TNFα is involved in the occurrence and development of diabetic vascular complications. Dynamic detection of serum TNFα levels can be used as an objective indicator of changes in the clinical course of diabetes mellitus.