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【目的】探讨鼠神经生长因子对糖尿病周围神经病变的临床治疗效果。【方法】选择本院2012年3月至2014年2月收治的82例糖尿病周围神经病变患者为研究对象，随机分为对照组与观察组，每组41例患者，对照组采取甲钴胺注射液治疗，观察组行鼠神经生长因子肌肉注射治疗，对两组患者治疗前后的血压、血脂、血糖水平进行分析，并观察比较两组患者治疗前后睡眠质量评分（QS）及高敏C‐反应蛋白（hs‐CRP）水平，判断治疗前后两组患者的腓总神经、正中神经及胫神经的感觉传导速度（SNCV ）、运动传导速度（M NCV ）变化情况，分析临床疗效。【结果】观察组治疗总有效率为92．68％，对照组为70．73％，观察组治疗有效率显著高于对照组，且两组相比较差异有显著性（ P ＜0．05）；两组患者治疗前后收缩压、舒张压对比均无明显差异（ P ＞0．05）；两组治疗前后三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白（LDL‐C）、高密度脂蛋白（HDL‐C）、糖化血红蛋白（HbA1c）相比较差异均无显著性（ P＞0．05）；两组患者M NCV、SNCV评分较治疗前均有明显改善，且观察组治疗后评分优于对照组（ P ＜0．05）；QS评分治疗后明显低于治疗前，且观察组显著低于对照组（ P ＜0．05）；hs‐CRP水平经治疗后，两组患者均有下降，观察组明显低于对照组（ P ＜0．05）。【结论】鼠神经神长因子对糖尿病周围神经病变治疗效果显著，可有效提高患者生活质量，值得临床进一步推广使用。“,”[Objective] To explore the clinical efficacy of mouse nerve growth factor for peripheral diabetic neuropathy .[Methods] From March 2012 to February 2014 ,a total of 82 patients with peripheral diabetic neuropathy were recruited and randomly divided into observation and control groups ( n=41 each) .The con‐trol group received an injection of mecobalamin while the observation group had an intramuscular injection of mouse nerve growth factor .The blood levels of fat ,sugar and high sensitivity C‐reactive protein (hs‐CRP) , blood pressure ,sleep quality score ,sensory nerve conduction velocity (SNCV)& motor nerve conduction ve‐locity (MNCV) and clinical efficacies were compared before and after treatment .[Results]The overall efficacy rate of observation group was higher than that of control group (92 .68% vs 70 .73% ,P <0 .05) .Systolic or diastolic blood pressure showed no obvious inter‐group difference ( P 0 .05) .The post and pre‐treatment scores of MNCV and SNCV had obvious differ‐ences .However ,observation group fared better than control group after treatment ( P<0 .05) And the post‐treatment QS score of observation group was obviously lower than that of control group ( P <0 .05) .After treatment ,hs‐CRP decreased in both groups .However ,there was a greater decline in observation group ( P<0 .05) .[Conclusion]Mouse nerve growth factor has marked efficacy for peripheral diabetic neuropathy so as to effectively improve the patient life quality .And it is worthy of wider popularization .