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系统性红斑狼疮(SLE)是侵犯全身结缔组织的自身免疫性疾病。多见于青年女性,病因未明,临床表现多样复杂,死亡率高,诊断和治疗也存在不少问题。临床上多以红斑狼疮细胞作为化验诊断的重要依据,随后,某些学者又采用免疫萤光技术检查患者血清中抗核抗体(ANA)作为一项辅助诊断方法。 本文目的是用免疫萤光技术探讨血清中ANA对诊断SLE的意义及其与病情活动性的关系,力求寻找一个早期诊断,并把病情控制在亚临床复发水平以下的免疫监视指标。
Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks whole body connective tissue. More common in young women, the etiology is unknown, the clinical manifestations of diverse and complex, high mortality, there are many problems diagnosis and treatment. Clinically, Lupus erythematosus cells are the most important basis for laboratory diagnosis. Subsequently, some scholars also used immunofluorescence to examine anti-nuclear antibody (ANA) in serum of patients as an auxiliary diagnostic method. The purpose of this paper is to investigate the significance of serum ANA in the diagnosis of SLE and its relationship with disease activity by using immunofluorescence technique in order to find an immune surveillance indicator for early diagnosis and control of the disease below subclinical relapse.