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目的 探讨检测患者血清特异IgG4对脑囊虫病诊断和疗效考核的价值。方法 应用胶体金标记的抗人IgG4McAb为探针检测脑囊虫患者血清中的特异IgG4 ,并与其脑CT影像表现进行对比分析。结果 检测脑囊虫病患者血清特异IgG4阳性率为 97.8% ,除肝包虫病人血清出现弱交叉反应外 ,其它寄生虫病、中枢神经系统疾病和健康对照均为阴性 ;检测不同疗程脑囊虫病患者血清特异IgG4 ,发现随着疗程的增加 ,临床症状的好转 ,患者血清特异IgG4逐渐降低或消失 ,并且脑囊虫病患者血清特异IgG4的阳性率和阳性强度与囊尾蚴在脑组织内寄生的数量 ,以及存活、崩解、死亡、钙化等病理变化相一致 ,可客观地反映囊尾蚴在脑组织内的存活状态。结论 检测患者血清特异IgG4对脑囊虫病诊断和疗效考核具有较好的应用价值。
Objective To investigate the value of detecting serum specific IgG4 in the diagnosis and therapeutic evaluation of cerebral cysticercosis. Methods Colloidal gold labeled anti-human IgG4McAb was used as a probe to detect specific IgG4 in the serum of patients with cerebral cysticercosis and compared with that of brain CT images. Results The positive rate of serum specific IgG4 in patients with cerebral cysticercosis was 97.8%. Except for the presence of weak cross-reaction in serum of patients with hepatic hydatidosis, other parasitic diseases, central nervous system diseases and healthy controls were negative. Serum of patients with cysticercosis Specific IgG4 and found that as the course of treatment improved, clinical symptoms improved, serum IgG4 patients gradually decreased or disappeared, and the positive rate and positive intensity of serum specific IgG4 in patients with cysticercosis and cysticercosis in the brain tissue in the number of parasites and survival , Disintegration, death, calcification and other pathological changes consistent with the cysticercosis can be objectively reflected in the survival of brain tissue. Conclusion Detection of serum specific IgG4 in patients with cerebral cysticercosis diagnosis and efficacy evaluation has good value.