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对20例正常人和36例肺癌患者的染色体不稳定性和脆性部位进行研究,发现肺癌患者比正常人外周血淋巴细胞的染色体畸变率和脆性部位的检出率有明显增高。对于这一结果,特别是常见型脆性部位C-fra(3p14)和小细胞肺癌的del(3)(p14～23)染色体重排的可能关系进行了讨论。
In 20 cases of normal and 36 cases of lung cancer patients with chromosomal instability and brittle parts of the study found that lung cancer patients than normal peripheral blood lymphocyte chromosome aberration rate and the detection rate of brittle parts were significantly increased. The possible relationship between this result, especially the chromosomal rearrangement of C-fra (3p14), a common type of fragile site, and small cell lung cancer del (3) (p14-23) is discussed.