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通过使用耗散粒子动力学(DPD)模拟方法,对不同拓扑结构聚合物自组装胶束包载阿霉素(DOX)的载药性能进行了研究。模拟了五种相同嵌段种类不同拓扑结构的聚合物(PCL_(22)-PDEA_(25)-b-PPEGMA_5)n(n=1,3,4,5,6)自组装载药胶束体系,模拟过程中,不同拓扑结构聚合物都自组装为PCL(核)-PDEA(pH响应)-PEGMA(壳)三层结构的胶束。结果表明,随着聚合物臂数目的增加,具有偶数臂结构的聚合物胶束载药量显著减少,而具有奇数臂结构的聚合物胶束载药量无明显变化;且适当增加六均臂星形聚合物胶束的亲水嵌段比例能够明显提高胶束的稳定性和药物的包载量。
The drug loading properties of doxorubicin (DOX) loaded with self-assembled micelles with different topological structures were investigated by using dissipative particle dynamics (DPD) simulation method. Five polymers (PCL_ (22) -PDEA_ (25) -b-PPEGMA_5) n (n = 1,3,4,5,6) self-assembled drug loaded micelles with different topologies of the same block type In the simulation, different topological polymers self-assemble into micelles with PCL (core) -PDEA (pH response) -PEGMA (shell) three-layer structure. The results show that with the increase of the number of polymer arms, the drug loading of polymer micelles with an even number of arm structures decreases significantly, while the number of polymer micelles with odd number of arm structures shows no significant change. The hydrophilic block ratio of star polymer micelles can significantly improve the micellar stability and drug loading.