Osteoprotegerin Secretion by Mevastatin via p38MAPK and NF-kB

• 作 者: Helen Smith
• 机 构: InstituteofScienceTechoologyandMedicine
• 出 处: 风湿病与自身免疫疾病期刊(英文)
• 发表日期: 2012年2期
• 关键词: OSTEOPROTEGERIN OSTEOPOROSIS STATIN Mevastatin OsteoprotegerinOsteoporosisStatin

Osteoprotegerin (OPG) is a protein produced by many cell types that has the remarkable property of inhibiting bone loss. It does this by binding to the key bone resorptive cytokine, receptor activator of NF-kB ligand (RANKL). This cytokine is produced mai