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目的:探讨不同临床病理特征的乳腺非特殊型浸润性癌的分子亚型分布特点。方法:回顾性分析309例乳腺非特殊型浸润性癌患者的临床资料,根据患者年龄、绝经情况、组织学分级和淋巴结转移情况分组,每组再根据免疫组化雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(HER-2)结果分为4种不同的分子亚型,分析各组中不同分子亚型的分布特点。结果:309例乳腺非特殊型浸润性癌中Lumina A型为137例(44.3%),Lumina B型为64例(20.7%),HER-2/neu型为63例(20.4%),basal cell-like型为45例(14.6%)。不同年龄段、绝经与否、不同组织学分级和淋巴结转移情况患者的分子亚型差异均具有统计学意义(P<0.05)。结论:非特殊型浸润性癌的分子亚型以Luminal A型为主,其中异型性高,转移广泛的basal cell-like型的年龄分布呈现年轻化趋势。
Objective: To investigate the distribution of molecular subtypes of breast nonspecific invasive carcinoma of different clinical and pathological features. Methods: The clinical data of 309 breast cancer patients with non-specific invasive carcinoma were retrospectively analyzed. According to the age, menopause, histological grade and lymph node metastasis, each group was divided into three groups based on immunohistochemical estrogen receptor (ER) Progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2) results were divided into four different molecular subtypes, analysis of the distribution of different molecular subtypes in each group. Results: Of the 309 breast non-specific invasive carcinomas, 137 (44.3%) were Lumina A, 64 (20.7%) were Lumina B, 63 (20.4%) were HER-2 / neu, -like type was 45 cases (14.6%). There were significant differences in molecular subtypes between different age groups, menopause, different histological grade and lymph node metastasis (P <0.05). Conclusion: The molecular subtype of nonspecific invasive carcinoma is dominated by Luminal A type. The age distribution of basal cell-like type with high atypia and extensive metastasis shows a younger trend.