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一、历史1930年,首次在精液中发现具有降血压作用的一种物质,1935年将此物质命名为前列腺素(PG),1962年弄清了其化学结构,1971年又明确阿司匹林样物质具有阻碍PG合成的作用。1975年发现血栓烷(TX),1976年发现前列环素(PGI_2)。此外,1979、1984年,相继发现白三烯(LT)和LX(lipoxin)。数年间,这些PG关联物质的稳定诱导体、合成酶阻滞剂以及拮抗剂逐步被开发,随着病理作用的阐明,这些药剂的临床应用也在扩大。二、分类与代谢PG是以5个圆环为基本骨架,具有二个侧链的不饱和脂肪酸。根据侧链双键的结合数,分为三类。第1类是由二后莫-y-亚麻三烯酸产生的PGE_1等;第2类是由花生四烯酸产生的PGE_2、PGI_2等;第3类是由二十碳五烯酸产生的PGE_3等。在人体则以花生
First, the history In 1930, for the first time found in the semen has a hypotensive effect of a substance, in 1935 the substance named prostaglandin (PG), 1962 to clarify its chemical structure, 1971 and clear aspirin-like substance has Hinder the role of PG synthesis. Thromboxane (TX) was discovered in 1975 and prostacyclin (PGI_2) in 1976. In addition, 1979 and 1984, one after another found that leukotrienes (LT) and LX (lipoxin). For several years, the stable inducer, synthetase blocker and antagonist of these PG-related substances have been gradually developed. With the elucidation of pathological effects, the clinical application of these agents is also expanding. Second, classification and metabolism PG is based on five rings as the basic skeleton, with two side chains of unsaturated fatty acids. According to the number of side chain double bond, divided into three categories. The first is PGE_1 produced by the second Mo-y-flaxenic acid; the second is PGE_2, PGI_2 and so on produced by arachidonic acid; the third is the PGE_3 produced by the eicosapentaenoic acid Wait. In the human body is peanut