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氢氧化铝的乳剂、粉剂或片剂被广泛用作为抗酸剂和吸附剂。除这些制剂外,一些其它的铝化合物也用作抗酸剂,如甘氨酸铝、磷酸铝胶和碱式碳酸铝。甘氨酸铝显示出的可喜疗效鼓舞了许多科学工作者,于是对其它的氨基酸如麸氨酸、丙氨酸和赖氨酸的铝盐的抗酸值进行评价。近来的研究表明,需要制备一些氨基酸如麸氨酸、半胱氨酸和苯丙氨酸的铝盐和用不同方法来研究这些盐的抗酸值。本文综述了体外测定起始反应、反应速率、中和力和总酸消耗量的不同方法,其中不少方法并不完全是新的,仅是现有方法的改进。所设计的改进方法摸拟体内条件来评价抗酸剂剂量。
Aluminum hydroxide emulsions, dusts or tablets are widely used as antacids and adsorbents. In addition to these formulations, some other aluminum compounds are also used as antacids, such as glycine aluminum, aluminum phosphate gel, and basic aluminum carbonate. Many scientists have encouraged the pleasing effects of glycine aluminum, thus evaluating the acid resistance of other amino acids such as aluminum salts of glutamic acid, alanine and lysine. Recent studies have shown that it is necessary to prepare some aluminum salts of amino acids such as glutamic acid, cysteine and phenylalanine and to study the antacid value of these salts in different ways. In this paper, different methods of in vitro determination of initial reaction, reaction rate, neutralization force and total acid consumption are reviewed. Many of these methods are not entirely new and merely an improvement over the existing methods. The improved design methodology mimics in vivo conditions to assess antacid dose.