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目的 探讨微循环阻力指数(IMR)对比校正的心肌梗死溶栓(TIMI)计帧法(CTFC)在X综合征(CSX)诊断中的价值.方法 入选心电图平板运动试验阳性患者28例(X综合征组),运动试验阴性组28例(正常对照组),两组利用热稀释法测得IMR值,利用冠状动脉造影测算静息相校正的TIMI帧数(B-CTFC)、充血相校正的TIMI帧数(H-CTFC),将B-CTFC除以H-CTFC得出冠状动脉血流储备(CFRCTFC).比较两组间IMR、CTFC、CFRCTFC的相关性.结果 X综合征组高血压和糖尿病患者比例高于正常对照组(75％ vs 46.4％,60.7％ vs 28.6％,P＜0.05);X综合征组IMR高于正常对照组(39.5±27.6 vs 16.1 ±5.9,P＜0.01);X综合征组H-CTFC高于正常对照组(13.0±4.2 vs 9.5±2.4,P＜0.01);X综合征组CFRCTFC低于正常对照组(2.0 ±0.5 vs2.6±0.5,P＜0.01);IMR与CFRCTFC之间呈负相关(r=-0.62,P＜0.01).结论 IMR与校正的TIMI计帧法测定的CFRCTFC有显著的相关性,IMR可以用于评价X综合征患者冠脉微循环功能,对X综合征的诊断有一定的应用价值.“,”Objective To explore the correlation between the index of microcirculatory resistance (IMR) and the corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) in patients with cardiac syndrome X (CSX),and to discuss the value of IMR in the diagnosis of CSX.Methods This study selected 28 patients with positive treadmill exercise test (CSX group),and another 28 patients with negative treadmill exercise test (normal control group).First,the baseline CTFC (B-CTFC),and hyperemic CTFC (H-CTFC) were measured.The ratio of B-CTFC and H-CTFC was recorded as CFRCTFC.IMR was calculated by method of thermodilution.Results Proportion of patients with hypertension and diabetes in CSX group was significantly higher than that of normal control group (75％ vs 46.4％,60.7％ vs 28.6％,P ＜ 0.05).IMR in the CSX group was significantly higher than that in the normal group (39.5 ±27.6 vs 16.1 ±5.9,P ＜0.01).H-CTFC in the CSX group was significantly higher than that in the normal group (13.0 ±4.2 vs 9.5 ±2.4,P ＜0.01).CFRCTFCin the CSX group was significantly lower than that in the normal group (2.0 ±0.5 vs 2.6 ±0.5,P ＜0.01).IMR has significant correlation with CFRCTFC(r =-0.62,P ＜ 0.01).Conclusions IMR has a notable association with CFRCTFC calculated from CTFC.IMR can provide clinical application in the evaluation of coronary microcirculation dysfunction,and can be used in the diagnosis of CSX.