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目的研究症状性单侧颈动脉严重狭窄患者血管内支架成形术前后脑血管储备功能的变化。方法脑血管储备功能评估采用经颅多普勒超声(TCD)检测屏气导致的高碳酸血症对大脑中动脉血流速度的影响。比较15例症状性单侧颈动脉严重狭窄患者、15例无症状颈动脉狭窄患者和10例正常对照者的屏气指数，并比较分析15例症状性颈动脉狭窄患者在颈动脉支架成形术(CAS)前后的BHI的变化。结果症状性单侧颈动脉狭窄患者狭窄侧的BHI(0.50±0.2)明显低于无症状颈动脉狭窄患者的狭窄侧(0.90±0.3，<0.001)和正常对照组(1.14±0.3，0.05)。CAS术后症状性单侧颈动脉狭窄患者狭窄侧的BHI与术前相比明显改善(1.05±0.2，0.05)。结论症状性单侧颈动脉严重狭窄患者狭窄侧的脑血管储备功能受损明显，CAS术后显著改善。“,”Objective To Analyzethechangesofcerebrovascular reserve capability in symptomatic patients with unilateral severe carotidstenosis before and after carotid angioplasty and stenting (CAS). Methods Using transcranial Doppler (TCD),the cerebrovascular reserve capability was evaluated with the breath-holding index (BHI).The changes of flow velocity in the middle cerebral arteries after hypercapnia induced by breath-holdin were detected.We studied the BHI in 15 symptomatic and 15 asymptomatic patients with unilateral severe carotid stenosis and 10 control subjects.The changes of BHI in symptomatic patients with carotid stenosis before and after CAS were compared.Results BHI was significantly lower ( 0.05)in BHI was detected on the normal side of symptomatic(0.92±0.3)and asymptomatic(1.05±0.2)patients,and in control subjects.BHI significantly increased( <0.001)on the stenotic side(1.05±0.2)while remaining substantial y stable on the normal side of symptomatic patients (1.10±0.2)After CAS.Conclusion Impaired cerebrovascular reserve capability in the stenotic side of symptomatic patients with unilateral severe carotid stenosis were significantly improved after CAS.