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本文研究了两类普通附加剂——增塑剂和着色剂对水溶性的羟丙基甲基纤维素薄膜包衣性质的影响。实验中的增塑剂分别是甘油、丙二醇、聚乙二醇4000和聚乙二醇400;着色剂为二氧化钛,铝色淀、柠檬黄和二者各50％(w/w)的混合物,分别以35％(w/w)的量分散在水中备用。包衣水溶液中含固体总浓度为10％(w/w),然后进行包衣工艺。附加剂对薄膜包衣性质的影响主要包括如下。对片剂径向挤压强度的影响在衣膜中不含任何附加剂时,衣膜的量显著增加片剂的径向挤压强度,因而不易破碎。随着附加剂用量增加,衣膜的这种作用逐
This article studies the effects of two common types of additives, plasticizers and colorants, on the coating properties of water-soluble hydroxypropylmethylcellulose films. The plasticizers used in the experiments were glycerol, propylene glycol, polyethylene glycol 4000 and polyethylene glycol 400 respectively; the colorant was a mixture of titanium dioxide, aluminum lake, lemon yellow, and 50% (w / w) Dispersed in water at an amount of 35% (w / w). The total solids content of the aqueous coating solution is 10% (w / w) and the coating process is then carried out. The effects of the additives on the film coating properties include the following. Effect on radial compressive strength of the tablet In the absence of any additional agent in the film, the amount of film on the film significantly increases the crushing strength of the tablet and is therefore not easily broken. With the increase in the amount of additives, the role of clothing film by