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一、大环内酯物的概况所谓大环化合物,一般是指有12个碳原子以上的环状化合物,如果环上含有内酯键,即称大环内酯物。有一些生物碱具有大环内酯结构,也归属于大环内酯物,如Vertaline。“Macrolide”这个名词起先仅用于大环内酯抗生素类,后来被用于较广泛的范围,包括植物来源的大环内酯或大环内酰胺类。至今发现的大环内酰胺类化合物有20个左右,它们结构上的共同特点是具有芳香核的部分,在芳香核的不相邻的位置上连有一个长的脂肪桥,通过酰胺键连接,如众所周知的抗生素利福霉素B(Rifamycin B)、抗癌剂美登素(Maytasine)等均属于大环内酰胺类。自大环化合物发现以后,显示出拜耳张力学说的不全面性,按拜耳学说,大环化合物
First, the macrocyclic lactone overview The so-called macrocyclic compounds, generally refers to more than 12 carbon atoms of the cyclic compounds, if the ring contains lactone bonds, namely macrolide. Some alkaloids have macrolide structures and are also assigned to macrocyclic lactones, such as Vertaline. The term “Macrolide” was first used only for macrolide antibiotics and was later used in a wider range including macrolides or macrolides of plant origin. So far there are about 20 macrocyclic lactam compounds found structural common feature is the aromatic nucleus in the aromatic nucleus not adjacent to the location of a long chain of fat bridges connected by amide bonds, Such as the well-known antibiotic rifamycin B (Rifamycin B), anti-cancer agent maytasine (Maytasine) belong to macrolides. Since the discovery of the macrocyclic compound, it shows the incompleteness of Bayer’s theory of tension. According to Bayer’s theory, macrocycles