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为探讨化妆品的安全性，采用动物涂抹方法，对１０种新型化妆品进行了慢性皮肤刺激试验，结果为：粉饼Ⅰ、粉饼Ⅳ、湿粉Ⅱ、膏霜Ⅱ、膏霜Ⅲ为阴性反应，粉饼Ⅱ、粉饼Ⅲ、湿粉Ⅰ、湿粉Ⅲ和膏霜Ⅰ对兔皮肤均有不同程度的损伤。试验表明，某些化妆品肉眼观察与病理检查结果并不完全一致，肉眼观察结果相近的两种化妆品其病理检查结果有时差别也较大。另外，有的样品在慢性皮肤刺激试验中，肉眼观察出现刺激反应的时间过程较长，如果仅进行急性皮肤刺激试验，则为阴性结果。因此建议对于长期涂用的化妆品，最好能进行多次皮肤刺激试验，以避免对人体皮肤造成损害。
In order to explore the safety of cosmetics, 10 new types of cosmetics were subjected to chronic skin irritation test by animal smear method. The results were as follows: powder cake Ⅰ, cake Ⅳ, wet powder Ⅱ, cream Ⅱ, cream Ⅲ were negative, , Powder Ⅲ, wet powder Ⅰ, wet powder Ⅲ and cream Ⅰ have different degrees of damage to rabbit skin. Tests showed that some cosmetic macroscopic observation and pathological examination results are not exactly the same, macroscopic observation of similar results of the two kinds of cosmetics sometimes pathological examination results are also large differences. In addition, some samples in the chronic skin irritation test, the naked eye appears to stimulate the reaction time is longer, if only the acute skin irritation test, the negative result. Therefore, it is recommended that for long-term application of cosmetics, it is best to conduct multiple skin irritation test to avoid damage to human skin.