丙、丁、庚型肝炎同原发性肝癌的相关因素分析

• 作 者: 孙毅 孙晓欧 徐友
• 机 构: 解放军第一○○医院,苏州医学院附属第一医院
• 出 处: 实用医学杂志
• 发表日期: 1999年08期
• 关键词: 庚型肝炎 原发性肝癌

目的：探讨ＲＮＡ病毒引起的丙型、丁型、庚型肝炎同原发性肝癌（ＰＬＣ）发生的关系。方法：采用免疫病理观察比较丙型肝炎病毒ＮＳ５抗原（ＨＣＶＮＳ５），丁型肝炎病毒抗原（ＨＤＶＡｇ），庚型肝炎病毒ＮＳ５抗原（ＨＧＶＮＳ５）在肝细胞肝癌（ＨＣＣ）组织中的表达特点。结果：在７２例ＨＣＣ中ＨＣＶＮＳ５、ＨＤＶＡｇ、ＨＧＶＮＳ５检出率分别为２６３９％、１９４４％、６９４％，总检出率为２９１７％。三种抗原信号在癌组织及癌旁组织均有表达，但表达的主要部位有差异。三种抗原表达同ＨＣＣ的分化程度无明显相关性，同ＨＣＣ患者的预后有一定的相关性。结论：ＨＣＶ和ＨＤＶ同ＰＬＣ有密切关系，没有充分证据表明ＨＧＶ是ＰＬＣ发生的高危因素。

Objective: To investigate the relationship between hepatitis C, hepatitis D and g hepatitis caused by RNA virus and primary liver cancer (PLC). METHODS: The expression of hepatitis C virus NS5 antigen (HCVNS5), hepatitis D virus antigen (HDVAg) and hepatitis G virus NS5 antigen (HGVNS5) in hepatocellular carcinoma (HCC) tissues were compared by immunopathological observation. Features. Results: The detection rates of HCVNS5, HDVAg and HGVNS5 in 72 HCC patients were 2639%, 1944%, and 6.94% respectively. The total detection rate was 2917%. The three antigen signals were expressed in cancer tissues and adjacent tissues, but the main parts of the expression were different. There was no significant correlation between the expression of three antigens and the degree of differentiation of HCC, and there was a certain correlation with the prognosis of HCC patients. Conclusion: HCV and HDV are closely related to PLC. There is no sufficient evidence that HGV is a high risk factor for PLC.