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目的探讨2型糖尿痛(T2DM)患者应用盐酸二甲双胍素联合胰岛素治疗的临床效果。方法选取本院2012年1月至2012年12月收治的T2DM患者148例为研究对象,随机将患者分为单纯胰岛素治疗组(对照组)74例以及盐酸二甲双胍联合胰岛素治疗组(观察组)74例,对两组患者随访12周,对比分析两组患者的临床治疗效果。结果与治疗前相比,两组患者治疗后血糖均得到有效控制,差异有统计学意义(P<0.05),与对照组相比,观察组每日胰岛素所需量较低(P<0.05);与对照组相比,观察组高密度胆固醇水平较高(P<0.05),甘油三脂水平下降(P<0.05),胰岛素抵抗指数下降显著(P<0.05),B细胞功能上升(P<0.05),脂联素水平上升(P<0.05)。结论对T2DM患者应用盐酸二甲双胍与胰岛素联合治疗能有效改善患者血糖及血脂水平,提高胰岛素敏感性,提高患者脂联素水平,降低胰岛素抵抗作用,其临床效果优于单纯使用胰岛素治疗,安全可靠,无明显不良反应,值得临床应用。
Objective To investigate the clinical effect of metformin hydrochloride plus insulin in type 2 diabetic patients (T2DM). Methods A total of 148 patients with T2DM admitted from January 2012 to December 2012 in our hospital were randomly divided into two groups: control group (n = 74) and metformin plus insulin group (n = 74) Cases, two groups of patients were followed up for 12 weeks, comparative analysis of two groups of patients with clinical treatment. Results Compared with those before treatment, the blood glucose of the two groups were effectively controlled after treatment, the difference was statistically significant (P <0.05). Compared with the control group, the daily insulin requirement of the observation group was lower (P <0.05) (P <0.05), the level of triglyceride decreased (P <0.05), the index of insulin resistance decreased significantly (P <0.05) and the function of B cells increased (P < 0.05) and adiponectin level increased (P <0.05). Conclusions The combination therapy of metformin and insulin in patients with T2DM can effectively improve the level of blood glucose and blood lipid, improve the insulin sensitivity, increase the level of adiponectin and reduce the effect of insulin resistance in patients with T2DM. The clinical effect is better than that of insulin alone, which is safe and reliable. No significant adverse reactions, it is worth clinical application.