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目的:研究10 例脂膜炎性T细胞淋巴瘤的临床病理形态和生物学行为特点,为临床早期诊断提供依据。方法:运用组织病理学、免疫组化学及分子生物学技术,对10 例原发于皮下脂肪组织中的T细胞淋巴瘤进行临床病理学和免疫组织化学观察及EB 病毒的检测。结果:组织学上以肿瘤细胞(CD45RO阳性)浸润脂肪小叶之间及可见豆袋细胞(CD68 阳性) 为特征,部分患者肿瘤细胞EBV- DNA阳性。2 例患者分别于首诊1 年6 个月和2 年后死亡。结论:脂膜炎性T细胞淋巴瘤多为高度恶性,其发生可能与EBV感染有关
Objective: To study the clinicopathological features and biological behavior of 10 cases of Panniculoplasitic T-cell lymphoma and provide the basis for early clinical diagnosis. Methods: The histopathology, immunohistochemical and molecular biological techniques were used to detect the expression of Epstein-Barr virus (EBV) in 10 cases of primary T-cell lymphoma in subcutaneous adipose tissue. RESULTS: Histologically, tumor cells (CD45RO positive) were infiltrated between adipose lobules and seen bean pouch cells (positive for CD68). Some of the tumor cells were EBV-DNA positive. Two patients died at 6 months and 2 years after the first visit. Conclusion: Most of the TMPs are highly malignant and their occurrence may be related to EBV infection