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目的探讨癌基因C－erbB_2，在宫颈癌组织中表达的临床、病理及预后的关系。方法采用免疫组织化学方法，检测C-erbB_2在宫颈癌组织中表达情况，鳞癌87例，腺癌12例，正常宫颈组织8例，临床Ⅱ期4例，Ⅲ期95例。结果阳性染色定位细胞膜，87例鳞癌、12例腺癌，阳性率分别为58％、66％．正常宫颈组织明性。组织学1、2、3级阳性率分别为46％、56％、70．8％。临床Ⅱ期阳性率25％明显低于Ⅲ期61％。预后存活10年以上C－erbB_2阳性率47％，明显低于1年内死亡72．9％，P＜0．01。结论C－erbB_2蛋白高表达渴望成为一项估计宫颈癌患者预后的指标之一。
Objective To investigate the relationship between the expression of oncogene C-erbB 2 and clinical, pathological and prognosis in cervical cancer. Methods Immunohistochemistry was used to detect the expression of C-erbB_2 in cervical cancer. There were 87 cases of squamous cell carcinoma, 12 cases of adenocarcinoma, 8 cases of normal cervical tissue, 4 cases of stage Ⅱ and 95 cases of stage Ⅲ. Results Positive staining of the cell membrane, 87 cases of squamous cell carcinoma, 12 cases of adenocarcinoma, the positive rates were 58%, 66%. Normal cervical tissue is clear. The positive rates of histological grade 1, 2 and 3 were 46%, 56% and 70.8% respectively. The positive rate of clinical stage Ⅱ 25% was significantly lower than 61% of stage Ⅲ. The positive rate of C-erbB 2 that survived more than 10 years in prognosis was 47%, which was significantly lower than 72.9% of those in 1 year (P <0.01). Conclusions The high expression of C-erbB-2 protein is one of the prognostic factors in estimating the prognosis of cervical cancer patients.