论文部分内容阅读
目的:制备满山红总黄酮-聚乙二醇6000(PEG 6000)固体分散体,并考察其体外溶出度。方法:以PEG6000为载体,采用溶剂-熔融法制备3种不同比例的固体分散体,紫外分光光度法(以芦丁计)测定总黄酮含量,考察各固体分散体的体外溶出特性。结果:原料药在60 min内的累积释放度57.032%;满山红总黄酮-PEG6000 1∶2,1∶4,1∶6的固体分散体于60min的累积释放度分别为80.21%,91.43%,74.32%。结论:溶剂-熔融法制得的各比例固体分散体均能显著提高药物的溶出速率。
Objective: To prepare a solid dispersion of total flavonoids of Polygala root-polyethylene glycol 6000 (PEG 6000) and investigate its in vitro dissolution. Methods: Three kinds of solid dispersions were prepared by solvent-melt method using PEG6000 as carrier. The content of total flavonoids was determined by ultraviolet spectrophotometry (rutin), and the in vitro dissolution characteristics of each solid dispersion were investigated. Results: The cumulative release of drug substance in 60 min was 57.032%. The cumulative release of the total flavonoids of Mangosteen-PEG6000 1: 2, 1: 4 and 1: 6 at 60 min was 80.21% and 91.43% , 74.32%. Conclusion: The solid dispersions prepared by solvent-melt method can significantly improve the drug dissolution rate.