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目的观察多西紫杉醇(DOC)联合奥沙利铂(OXA)治疗局限性晚期子宫颈癌的疗效、毒副反应及生存期。方法局限性晚期子宫颈癌患者16例,给予DOC 60 mg/m2,OXA 100 mg/m2,第1天,经两侧髂内动脉灌注(分别持续1 h和2 h),每21 d为1个周期。每6周MRI检查1次。结果CR 3例,PR 11例,PD 2例,总有效率(ORR)为87.5%,初治患者为100.0%(CR 3例,PR 4例),复治患者为77.8%(PR 7例,PD 2例)。初治和复治患者的中位生存期分别为12个月和11个月。毒性反应主要有粒细胞减少(Ⅲ~Ⅳ度粒细胞减少占10.2%)和感觉神经异常,其他有脱发(100%)、恶心呕吐、皮肤病变、黏膜炎、贫血及血小板减少等。结论多西紫杉醇联合奥沙利铂治疗局限性晚期子宫颈癌疗效明显,毒性反应可以耐受。
Objective To observe the efficacy, side effects and survival of docetaxel combined with oxaliplatin (OXA) in the treatment of locally advanced cervical cancer. METHODS: Twenty-six patients with advanced cervical cancer were treated with DOC 60 mg / m2 and OXA 100 mg / m2 on day 1 with bilateral internal iliac artery perfusion (1 h and 2 h, respectively) and 1 d A cycle. MRI examination every 6 weeks. Results There were 3 cases of CR, 2 cases of PR and 2 cases of PD. The total effective rate (ORR) was 87.5%, the initial treatment was 100.0% (CR 3 cases, PR 4 cases) and the retreatment was 77.8% (PR 7 cases, PD 2 cases). The median survival of patients in both initial and retreatment groups was 12 months and 11 months, respectively. Toxic reactions are mainly neutropenia (Ⅲ ~ Ⅳ neutropenia accounted for 10.2%) and sensory nerve abnormalities, the other with hair loss (100%), nausea and vomiting, skin lesions, mucositis, anemia and thrombocytopenia. Conclusion Docetaxel combined with oxaliplatin in the treatment of locally advanced cervical cancer has obvious curative effect and tolerable toxicity.