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目的通过比较男性不育症患者和健康男性的精浆微量元素与精子质量的相关性,探讨锌、铜、铅等微量元素对精子质量的影响。方法选择183例男性不育症患者与183例健康男性,检测精液常规和精浆中锌、铜、铅的含量,分析锌、铜、铅的含量与精子密度、活动率、活力的相关性。结果不育组的精子质量显著低于对照组,其精浆中锌显著低于对照组,铅含量显著高于对照组,铜在两组间差异无显著性。同时,精浆中锌含量与精子密度、活动率、活力(a、b)呈显著正相关,与活力d呈显著负相关,铅含量与上述相反。铜与精子质量无显著相关性。结论精浆中锌可增加精子密度及活动率,增加a级和b级活力比例其作用机制可能与促进精子生成、成熟等有关,而铅可对精子质量呈现毒性作用。
Objective To explore the effect of trace elements such as zinc, copper and lead on sperm quality by comparing the correlation between trace elements in sperm and sperm quality in male infertility patients and healthy men. Methods 183 cases of male infertility and 183 healthy men were selected. The levels of zinc, copper and lead in seminal fluid and seminal plasma were detected. The correlations between zinc, copper and lead contents and sperm density, activity and vitality were analyzed. Results The sperm quality of the sterile group was significantly lower than that of the control group. The zinc content in the seminal plasma of the sterile group was significantly lower than that of the control group. The content of lead in the sterile group was significantly higher than that in the control group. There was no significant difference in copper between the two groups. At the same time, zinc content in seminal plasma was positively correlated with sperm density, activity rate, vitality (a, b), negatively correlated with vitality d, and lead content was opposite to the above. Copper and sperm quality no significant correlation. Conclusion Zinc in seminal plasma can increase the density and activity of sperm, and increase the ratio of a and b vitality may be related to the promotion of spermatogenesis and maturation. However, lead may be toxic to sperm quality.