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15例鼻咽活检组织病理诊断为慢性炎症,而电镜检查却发现二例有微小浸润癌(其中一例数月后病理理诊断为鼻咽癌)。此二例均是在非典型鳞状化生的基础上发生的,其底层具异型性的化生细胞通过缺损的基底膜向上皮的固有层浸润,浸润的方式多以伸出不同形状的伪足为特点,伪足还可有多级分支,末级分支处的胞膜往往模糊不清,这可能与其以阿米巴运动的方式使整个细胞侵入上皮的固有层有关。浸润的癌细胞3—5成群或索状排列形成微小的癌巢,巢内的癌细胞多具丝状、指状、翼状及球状突起,细胞间由胞浆突起互相疏松的连接,有时可见其间有发育不良的桥粒。癌细胞核大,常染色质丰富,核仁大而居中或靠核膜,胞浆基质电子密度致密或透亮,细胞器较少並多位于核周,有数量不等的胞浆微丝或张力原纤
Fifteen cases of nasopharyngeal biopsies were histologically diagnosed as chronic inflammation, whereas electron microscopy revealed two cases of microinvasive carcinoma (one case was diagnosed nasopharyngeal carcinoma several months later). The two cases are based on atypical squamous metaplasia occurred on the basis of the bottom of the atypical metaplastic cells through the defect of the basement membrane epithelial infiltration into the lamina propria infiltration in the way to extend the pseudo-different shapes Pseudopodia may also have multiple branches, the membrane at the terminal branch is often blurred, which may be related to its invasion of the epithelial lamina propria of the entire cell with amoeba movement. Infiltrated cancer cells 3-5 groups or cord-like arrangement of tiny cancer nests, nests of cancer cells with more filaments, fingers, wings and globular protrusions, cells by the cytoplasm protruding loose connections, and sometimes visible During this period, dysplastic desmosomes are present. Cancer cells large, often rich in chromatin, large nucleoli and the central or by the nuclear membrane, cytoplasm dense or translucent electron density, less organelles and more in the perinuclear weeks, with varying amounts of cytoplasmic microfilament or fibrillation