妊娠期糖尿病血糖波动特征

• 作 者: 陈卫军 赵丽华 苏建彬 金艳 徐峰 高丹 王雪琴
• 机 构: 南通大学第二附属医院护理部,南通大学第二附属医院内分泌科,
• 出 处: 江苏医药
• 发表日期: 2014年21期
• 关键词: Gestational diabetes mellitus Dynamic monitoring of blood glucose

目的分析妊娠期糖尿病(GDM)患者血糖波动特征。方法对孕24-28周妊娠期糖尿病患者30例(GDM组)、正常妊娠妇女20例(NGW组)和正常糖耐量非妊娠妇女20例(NGR组)采用CGMS进行持续72h血糖监测。根据血糖谱计算日内血糖平均值(MBG)及其标准差(SD)、日内平均血糖波动幅度(MAGE)和日间血糖平均绝对差(MODD)。结果 GDM组的MBG和MAGE为(8.6±2.3)mmol/L和(3.5±0.9)mmol/L,高于NGW组的(6.2±1.8)mmol/L和(2.3±0.7)mmol/L(P<0.05)和NGR组的(4.8±1.6)mmol/L和(1.7±0.5)mmol/L(P<0.01)。GDM组的MODD和SD高于NGR组和NGW组(P<0.05);但NGR组和NGW组的MODD和SD无统计学差异(P>0.05)。结论 GDM患者的血糖波动性明显高于正常妊娠妇女。采用CGMS进行持续血糖监测可以为临床干预提供依据。

Objective To analyze the characteristics of blood glucose fluctuation in patients with gestational diabetes mellitus (GDM). Methods Thirty (GDM) gestational diabetes mellitus (gestational age 24-28 weeks), 20 normal pregnant women (NGW group) and 20 normal non-pregnant women with glucose tolerance (NGR group) were monitored by CGMS for 72 hours. Daily mean blood glucose (MBG) and its standard deviation (SD), intraday average blood glucose fluctuation (MAGE) and mean daytime blood glucose (MODD) were calculated based on glycemic profiling. Results The MBG and MAGE in GDM group were (8.6 ± 2.3) mmol / L and (3.5 ± 0.9) mmol / L, respectively, higher than those in NGW group (6.2 ± 1.8 mmol / L and 2.3 ± 0.7 mmol / L <0.05) and (4.8 ± 1.6) mmol / L and (1.7 ± 0.5) mmol / L (P <0.01) in NGR group, respectively. The MODD and SD in GDM group were higher than those in NGR group and NGW group (P <0.05), but there was no significant difference in MODD and SD between NGR group and NGW group (P> 0.05). Conclusion The blood glucose of GDM patients is significantly higher than that of normal pregnant women. Using CGMS for continuous glucose monitoring can provide a basis for clinical intervention.