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目的:探讨肾上腺皮质癌的诊断和治疗方法。方法:回顾性分析9例肾上腺皮质癌患者的临床资料,其中男7例,女2例。年龄5个月～63岁,平均39岁。术前全部行B超及CT检查,有内分泌异常者2例,分别为Cushing syndrome及原发性醛固酮增多症。无内分泌异常者7例。结果:手术完整切除9例。术后病理检查:Ⅰ期1例;Ⅱ期4例;Ⅲ期3例;Ⅳ期1例。随访4～60个月,平均生存30个月,1例因肺部转移而术后26个月死亡,1例失去随访,其余7例均存活至今。结论:肾上腺皮质癌恶性程度较高,预后较差,根治性切除是治疗肾上腺皮质癌最有效的方法。化疗及放疗可作为术后辅助治疗。早期诊断和早期治疗可提高患者生存率。
Objective: To investigate the diagnosis and treatment of adrenocortical carcinoma. Methods: The clinical data of 9 patients with adrenocortical carcinoma were analyzed retrospectively, including 7 males and 2 females. Aged 5 months to 63 years old, average 39 years old. All patients underwent preoperative ultrasound B and CT examination, 2 cases of endocrine abnormalities were Cushing syndrome and primary aldosteronism. No endocrine abnormalities in 7 cases. Results: Nine cases were completely resected. Postoperative pathological examination: stage Ⅰ in 1 case, stage Ⅱ in 4 cases, stage Ⅲ in 3 cases and stage Ⅳ in 1 case. All patients were followed up for 4 to 60 months with an average survival of 30 months. One patient died of lung cancer 26 months after operation and one patient lost follow-up. The remaining seven patients survived so far. Conclusion: Adrenal cortical carcinoma has higher malignancy and poor prognosis. Radical resection is the most effective method for the treatment of adrenocortical carcinoma. Chemotherapy and radiotherapy can be used as adjuvant therapy. Early diagnosis and early treatment can improve patient survival.