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目的 :探讨巴曲抗栓酶对大鼠肠系膜微动脉血栓的疗效和作用机制。方法 :SD大鼠 2 4只 ,分成 3组 ,0 .9%氯化钠注射液对照组、巴曲抗栓酶 8BU·kg- 1和 16BU·kg- 12个剂量组 ,每组为 8只。分别采用光化学诱导法制作大鼠肠系膜微动脉血栓 ,经显微电视摄像系统和多媒体计算机图象处理技术相结合 ,对巴曲抗栓酶的疗效进行定量分析。结果 :巴曲抗栓酶 8BU·kg- 1组再通率为 38%(3/ 8) ,平均再通时间为 (2 7±s9)min ;16BU·kg- 1组再通率为 50 % (4 / 8) ,平均再通时间为 (34± 2 1)min。结论 :巴曲抗栓酶对大鼠微动脉血栓具有可靠的治疗效果
Objective: To investigate the efficacy and mechanism of batroxobin on mesenteric arterial thrombosis in rats. Methods: Twenty-four Sprague-Dawley rats were divided into three groups: 0.9% sodium chloride injection control group, 8 ku · kg-1 and 16BU · kg- . The mesenteric arteriole thrombosis was made by photochemical induction method. The curative effect of batroxobin was quantitatively analyzed by the combination of the microscopic television camera system and the multimedia computer image processing technology. Results: The recanalization rate was 38% (3/8) in the 8BU · kg-1 group and the mean recanalization time was (27 ± s9) min. The recanalization rate in the group of 16BU · kg-1 was 50% (4/8), the average recanalization time was (34 ± 2 1) min. Conclusion: Batroxobin has a reliable therapeutic effect on micro-arterial thrombosis in rats