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目的利用临床前列腺癌Gleason病理分级系统分析比较基因敲入(KIMAP)和转基因(TGMAP)小鼠前列腺癌模型。方法依照前列腺癌临床诊断的Gleason五级10分制的组织学分级和评分标准,对96例KIMAP和44例TGMAP前列腺癌标本进行了分析,并与临床前列腺癌进行了比较。结果KIMAP的组织学评分分布在4-9范围内,而TGMAP组织学评分全部分布在高数值范围内(6-10)。KIMAP小鼠(52.1%)比TGMAP小鼠(25.0%)表现出更高的混合组织学评分率,更接近于临床平均值(50.0%)。结论由于KIMAP模型成功地模仿了人类前列腺癌特征,在前列腺癌临床前期研究中具有潜在的应用价值。
OBJECTIVE: To compare the clinical prostatic cancer Gleason pathological grading system with the comparative gene knock in (KIMAP) and transgenic (TGMAP) mouse models of prostate cancer. Methods 96 cases of KIMAP and 44 cases of TGMAP prostate cancer were analyzed according to the histological grading and grading criteria of Gleason grade 10 in clinical diagnosis of prostate cancer and compared with clinical prostate cancer. Results The histological scores of KIMAP ranged from 4-9, while the histological scores of TGMAP all ranged from high values (6-10). KIMAP mice (52.1%) showed higher rates of mixed histology scores than TGMAP mice (25.0%), closer to the clinical mean (50.0%). Conclusion Because KIMAP model successfully mimics the characteristics of human prostate cancer, it has potential value in the preclinical study of prostate cancer.