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为探讨支气管哮喘与血浆内皮素、降钙素基因相关肤水平的关系。选择哮喘发作期患者12例,于发作期及缓解期和对照组20例,测定其静脉血浆内皮素(ET)、降钙素基因相关肽(CGRP)水平。结果支气管哮喘发作期的患者血浆中ET、CGRP水平高于缓解期和对照组(P<0.01);而缓解期的患者与对照组无明显差异(P>0.05)。结果提示支气管哮喘急性发作期患者血浆ET、CGRP释放增加,可能是促进哮喘气道炎症反应的发病机制之一。
To investigate the relationship between bronchial asthma and plasma endothelin, calcitonin gene-related skin levels. Twelve patients were selected during the attack period, and 20 patients in the attack and remission period and the control group. The levels of endothelin (ET) and calcitonin gene related peptide (CGRP) were measured. Results The levels of plasma ET and CGRP in patients with bronchial asthma were significantly higher than those in remission and control groups (P <0.01). There was no significant difference between patients in remission stage and control group (P> 0.05). The results suggest that patients with bronchial asthma acute exacerbation of plasma ET, CGRP release may be one of the pathogenesis to promote airway inflammation of asthma.