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作者采用安慰剂双盲法,观察了舌下给予硝苯吡啶(心痛定)的急性降压作用。本组高血压患者45例(原发性高血压25例、肾血管性高血压10例、慢性肾盂肾炎性高血压10例),男32例,女13例,年龄25～65岁。实验前2周停用所有降压药物,实验开始后每日早晨给予硝苯吡啶或安慰剂1次。实验的第1周每晨给予安慰剂,对第7天舒张压仍高于100毫米汞柱者继续进行观察。实验的第9、11、13和15天,分别给予硝苯吡啶5、10、20和30毫克,第10、12及14天,均给予安慰剂。给药前及给药后7小时内反复测量血压。
The authors used placebo double-blind method to observe the sublingual nifedipine (nifedipine) of the acute antihypertensive effect. This group of 45 patients with hypertension (25 cases of essential hypertension, renovascular hypertension in 10 cases, chronic pyelonephritis in 10 cases), 32 males and 13 females, aged 25 to 65 years. All antihypertensive drugs were discontinued 2 weeks prior to the experiment, and nifedipine or placebo was administered to each morning after the start of the experiment. The first week of the experiment was given placebo in the morning and continued observation of diastolic blood pressure above 100 millimeters on day seven. On days 9, 11, 13 and 15 of the experiment, nifedipine was administered at 5, 10, 20 and 30 mg, respectively, and placebo was administered on days 10, 12 and 14. Blood pressure was measured repeatedly before administration and within 7 hours after administration.