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目的:研究冠心病并代谢综合征(MS)患者血清糖基化终末产物(AGE)含量的变化及其临床意义。方法:选择单纯MS患者(A组)32例,单纯冠心病患者(B组)36例,冠心病并MS患者(C组)39例和正常对照(D组)28例。对所有受试者测量其身高、体重、腰围(WC)、臀围(HC);测血脂、空腹血糖(FBG)、胰岛素(FIN)、AGE;计算体质指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR)并进行比较。结果:A、B、C组患者的FIN、HOMA-IR、AGE均高于D组,C组的HOMA-IR、AGE分别高于A、B组。直线相关分析显示,HOMA-IR与BMI、WC、TG、FBG、FIN和AGE呈正相关,与HDL呈负相关。结论:冠心病并MS患者AGE的表达异常升高。
Objective: To study the changes of serum levels of advanced glycation end products (AGEs) in patients with coronary heart disease and metabolic syndrome (MS) and its clinical significance. Methods: Thirty-two patients with simple MS (group A), 36 patients with simple coronary heart disease (group B), 39 patients with coronary heart disease and MS (group C) and 28 normal controls (group D) were enrolled. Body height, weight, waist circumference (WC) and hip circumference (HC) were measured in all subjects; serum lipid, fasting blood glucose (FBG), insulin (FIN) and AGE were measured; body mass index (BMI), WHR ), Insulin resistance index (HOMA-IR) and compared. Results: The FIN, HOMA-IR and AGE of A, B and C groups were higher than that of D group. The HOMA-IR and AGE of C group were higher than those of A and B groups respectively. Linear correlation analysis showed that HOMA-IR was positively correlated with BMI, WC, TG, FBG, FIN and AGE, and negatively correlated with HDL. Conclusion: AGE expression in patients with coronary heart disease and MS is abnormally elevated.