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作者实验观察了内毒素致热反应时,对家兔体温及外周血白细胞(WBC)影响的变化规律。内毒素注入机体后半小时可见体温开始升高,并能维持4小时,与实验前相比P<0.01。而外周血WBC在体温升高的1～3小时内明显减少,与实验前相比P<0.01。从第4小时开始外周血WBC总数显著增加,与实验前相比P<0.01。掌握内毒素发热反应时体温及外周血WBC的变化规律,对临床病原菌感染的诊断及鉴别诊断有重要意义。
The authors observed experimentally the changes in the effects of endotoxin-induced fever on body temperature and peripheral white blood cells (WBC) in rabbits. Half an hour after the endotoxin was injected into the body, body temperature began to rise, and it could maintain 4 hours, compared with P<0.01 before the experiment. Peripheral blood WBC decreased significantly within 1 to 3 hours of the increase in body temperature, compared with P<0.01 before the experiment. From the 4th hour, the total number of WBC in peripheral blood increased significantly, compared with P<0.01 before the experiment. To grasp the changes of body temperature and peripheral blood WBC during endotoxin fever reaction is of great significance in the diagnosis and differential diagnosis of clinical pathogenic bacteria infection.