论文部分内容阅读
目的研究垂体瘤转化基因(PTTG)的表达与唾液腺腺样囊性癌(SACC)临床病理特点之间的关系。方法应用免疫组织化学SP法检测40例SACC组织及20例癌旁非癌组织中PTTG的表达。采用SPSS11.5统计软件包,应用χ2检验对结果数据进行统计学处理。结果 SACC组织中PTTG的表达明显升高,与非癌组织之间的差异具有统计学意义(P<0.05)。PTTG的表达与SACC的病理类型无关(P>0.05)。结论 PTTG在SACC组织中呈高表达。PTTG的表达与SACC的发生密切相关,PTTG的异常激活是SACC恶性增殖的原因之一。
Objective To study the relationship between the expression of PTTG and clinicopathological features of salivary adenoid cystic carcinoma (SACC). Methods Immunohistochemical SP method was used to detect the expression of PTTG in 40 SACC tissues and 20 adjacent non-cancerous tissues. Using SPSS11.5 statistical software package, using χ2 test to analyze the result data. Results The expression of PTTG in SACC tissues was significantly higher than that in non-cancerous tissues (P <0.05). The expression of PTTG was not related to the pathological type of SACC (P> 0.05). Conclusion PTTG is highly expressed in SACC tissues. The expression of PTTG is closely related to the occurrence of SACC. Abnormal activation of PTTG is one of the reasons for the malignant proliferation of SACC.