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本文报道应用免疫酶法检测234例鼻咽癌患者血清 EB 病毒抗体。放疗前 VCA—IgA 抗体阳性率为97%,几何平均滴度(GMT)为109.26,明显高于对照组(扁桃体癌35例,正常人140例)。抗体阳性率和 GMT 与 TNM 分期、肿瘤大小、淋巴结转移程度及病理类型无明显关系。EA—IgA 抗体阳性率则为56%。鼻咽癌经放疗5年以上者 VCA—IgA 抗体阳性率及 GMT 明显下降,对远期临床观察疗效具有一定意义。
This article reported the application of immunoenzymatic method to detect serum EB virus antibodies in 234 patients with nasopharyngeal carcinoma. The positive rate of VCA-IgA antibody before radiotherapy was 97%, and the geometric mean titre (GMT) was 109.26, which was significantly higher than that of the control group (35 cases of tonsillar cancer and 140 cases of normal people). The positive rate of antibodies and GMT had no significant relationship with TNM stage, tumor size, lymph node metastasis, and pathological type. The positive rate of EA-IgA antibody was 56%. The positive rate of VCA-IgA antibody and GMT were significantly decreased in patients with nasopharyngeal carcinoma who were treated with radiotherapy for more than 5 years. It has certain significance for the long-term clinical observation of curative effect.