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为探讨氯化甲基汞对雌性动物生殖系统的影响，采用氯化甲基汞给雌性昆明种小鼠急性染毒，剂量为１／２００ＬＤ５０、１／２０ＬＤ５０和１／２ＬＤ５０。染毒后采用ＦＡＣ－Ｓｃａｎ流式细胞仪技术分析了氯化甲基汞对卵巢细胞周期的影响。结果表明：１／２０ＬＤ５０组和１／２ＬＤ５０组中处于Ｇ０／Ｇ１期时相的细胞百分数高于对照组（Ｐ＜０．０５），而１／２０ＬＤ５０组和１／２ＬＤ５０组的Ｓ期时相的细胞的百分数明显低于对照组（Ｐ＜０．０５），其它无明显改变。研究表明，甲基汞可以造成Ｇ１期细胞增加，出现明显的Ｇ１阻滞，ＤＮＡ合成受抑制，细胞的有丝分裂延迟
In order to investigate the effect of methylmercury chloride on female reproductive system, female Kunming mice were acutely exposed to methylmercury chloride at doses of 1 / 200LD50, 1 / 20LD50 and 1 / 2LD50. The effect of methylmercury chloride on ovarian cell cycle was analyzed by FAC-Scan flow cytometry after exposure to the virus. The results showed that the percentage of cells in G0 / G1 phase in 1 / 2LD50 group and 1 / 2LD50 group was higher than that in control group (P <0.05), but the S phase in 1 / 20LD50 group and 1 / 2LD50 group Of the cells was significantly lower than the control group (P <0.05), the other no significant change. Studies have shown that methylmercury can cause G1 phase cells increased, there was a significant G1 block, DNA synthesis was inhibited, delayed cell mitosis