Lentivirus-mediated knockdown of phosphodiesterase 4D improved depression-like behaviors in mice

• 作 者: ZHANG Cong CHENG Yu-fang NIU B
• 机 构: GuangdongProvincialKeyLaboratoryofNewDrugScreening
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2016年10期
• 基金项目: The project supported by National Natural Science Foundation of China(81301099,81373384),Natural Science Foundation of Guangdong Province(S2013040014202),China Postdoctoral Science Foundation(2013M542

OBJECTIVE To examine whether long-form phosphodiesterase-4(PDE4)knockdown by lentiviral RNA construct containing a speci fi c micro RNA/mi RNAmir hairpin structure reversed depression-like symptoms caused by chronic unpredictable mild stress(CUMS)in mice.