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研究了白藜芦醇苷(polydatim,PD)的抗血栓形成作用及其作用机制。采用小鼠尾静脉注射花生四烯酸(arachidonicacid,AA)、电刺激大鼠颈动脉血栓形成方法评价PD的抗血栓形成作用;运用放射免疫法测定polydatin对兔血浆血栓素B2(thromboxaneB2,TXB2)及6酮前列腺素F1α(6ketoprostaglandinF1α,6ketoPGF1α)水平的影响。结果显示PD对AA、电刺激大鼠颈动脉引起的血栓形成具有明显的对抗作用;PD亦能降低兔血浆TXB2含量并升高6KetoPGF1α水平。本实验提示PD有明显的抗血栓形成作用,其机制可能与其降低血浆TXB2含量及升高6KetoPGF1α水平密切相关。
The antithrombotic effect of polydatin (PD) and its mechanism were studied. Rats were treated with arachidonic acid (AA) by tail vein injection to evaluate the antithrombotic effect of PD by electrical stimulation of carotid thrombosis in rats. Plasma thromboxane B2 (TXB2) was measured by radioimmunoassay in rabbits with polydatin. The effects of 6-ketoprostaglandin F1α (6 ketoPGF1α) levels. The results showed that PD had obvious antagonistic effects on AA and electrical stimulation of thrombosis caused by carotid artery in rats; PD also reduced rabbit plasma TXB2 content and increased 6KetoPGF1α levels. This experiment suggests that PD has a significant antithrombotic effect, and its mechanism may be closely related to its decrease plasma TXB2 content and increase the level of 6KetoPGF1α.