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目的:探讨微血管密度和中期因子在宫颈上皮内瘤变及宫颈鳞癌患者中的表达,并分析其临床意义。方法:选择宫颈上皮内瘤变患者22例、宫颈鳞癌患者28例及22例子宫内膜组织正常患者为研究对象,对比分析其微血管密度和中期因子表达情况。结果:中期因子表达阳性子宫内膜正常组0例,宫颈上皮内瘤变组5例,宫颈鳞癌组14例,各组间差异有统计学意义(P<0.05)。微血管密度子宫内膜正常组中为(7.7±4.9),宫颈上皮内瘤变组中为(10.6±5.6),宫颈鳞癌组中为(25.1±8.4),各组间差异有统计学意义(P<0.05)。结论:中期因子的阳性表达和微血管密度与宫颈上皮内瘤变及宫颈鳞癌密切相关,可作为宫颈癌变的监测指标。
Objective: To investigate the expression of microvessel density and midkine in cervical intraepithelial neoplasia and cervical squamous cell carcinoma, and to analyze its clinical significance. Methods: Twenty-two patients with cervical intraepithelial neoplasia, 28 patients with cervical squamous cell carcinoma and 22 patients with normal endometrium were enrolled in this study. The microvessel density and expression of midkine were compared. Results: There were 0 cases in normal group, 5 cases in cervical intraepithelial neoplasia group and 14 cases in cervical squamous cell carcinoma group, the difference was statistically significant (P <0.05). The microvessel density was (7.7 ± 4.9) in the normal endometrium group, (10.6 ± 5.6) in the cervical intraepithelial neoplasia group and (25.1 ± 8.4) in the cervical squamous cell carcinoma group, the difference was statistically significant P <0.05). Conclusion: The positive expression of midkine and microvessel density are closely related to cervical intraepithelial neoplasia and squamous cell carcinoma of cervix, which can be used as the monitoring indicators of cervical cancer.