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目的:通过随机对照实验观察硫辛酸联合依帕司他治疗糖尿病周围神经病变的临床疗效。方法:将糖尿病周围神经病变患者148例随机分为两组,在控制血糖的基础上,一组单用硫辛酸,另一组采用硫辛酸联合依帕司他治疗,2周后观察症状体征的变化及神经电生理的改变;结果:联合治疗组的总有效率(90.5%)优于硫辛酸组(68.9%),差异(P<0.05)两组治疗后MNCV与SNCV均较前提高,但联合组提高更明显(P<0.01);结论:硫辛酸联合依帕司他治疗能明显改善糖尿病周围神经病变的临床症状及神经传导速度,且无不良反应;
Objective: To observe the clinical efficacy of lipoic acid combined with epalrestat in the treatment of diabetic peripheral neuropathy by randomized controlled trials. Methods: 148 patients with diabetic peripheral neuropathy were randomly divided into two groups. On the basis of controlling blood glucose, one group was treated with lipoic acid alone and the other group was treated with lipoic acid combined with epalrestat. The symptoms and signs were observed after 2 weeks (90.5%) in the combined treatment group was superior to that in the lipoic acid group (68.9%). The difference was significant (P <0.05). After treatment, the MNCV and SNCV in both groups were higher than those in the control group (P <0.01). Conclusion: The combination of lipoic acid and epalrestat can obviously improve the clinical symptoms and nerve conduction velocity of diabetic peripheral neuropathy without any adverse reaction.