O-半乳吡喃糖基N,N-二(2-氯乙基)磷酰二胺酯的合成及其晶体结构

• 作 者: 陈茹玉 陈小茹 王如骥 王宏根
• 机 构: 南开大学元素有机化学研究所,南开大学元素有机化学研究所,南开大学中心实验室,南开大学中心实验室 天津 300071,天津 300071
• 出 处: 高等学校化学学报
• 发表日期: 1993年10期
• 关键词: 晶体结构 N 磷酰 标题化合物 糖基 单斜晶系 二胺 吡喃 磷原子 结构分析结果

为探讨糖基磷酰胺酯类化合物的抗肿瘤活性,用三氯氧磷作磷酰化试剂,合成了标题化合物.通过重结晶,分离出标题化合物的一个纯异构体.经X射线衍射单晶结构分析,该晶体属单斜晶系,空间群P2_1,a=1.3474(5)nm,b=1.0624(4)nm,c=1.6916(5)nm,β=110.55(3)°,z=4,D_x=1.35g/cm~3.收集到独立衍射点4379个,其中2159个为可观测点.最终一致性因子R=0.079.结构分析结果表明,反应中形成的手性磷原子为R构型.

To investigate the antitumor activity of glycosylphosphatidyl ester compounds, the title compound was synthesized using phosphorus oxychloride as a phosphorylating reagent.An isomer of the title compound was isolated by recrystallization.All samples were characterized by X-ray diffraction The crystal structure is monoclinic with space group P2_1, a = 1.3474 (5) nm, b = 1.0624 (4) nm, c = 1.6916 (5) nm and β = 110.55 4, D_x = 1.35g / cm ~ 3. 4379 independent diffraction points were collected, of which 2159 were observable points. The final consistency factor R = 0.079. Structural analysis showed that the chiral phosphorus atom formed in the reaction was R structure.