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目的:观察阿托伐他汀钙片对维持性血液透析(M HD)患者微炎症状态因子白介素 -1(IL -1)、白介素 -6(IL -6)的疗效. 方法:54例慢性肾功能衰竭维持性血液透析患者 ,随机分为对照组和治疗组各27例.对照组予以降低血压、纠正贫血、纠正酸中毒、纠正肾性骨病及维持性血液透析等常规治疗 ,治疗组在降低血压、纠正贫血、纠正酸中毒、纠正肾性骨病及维持性血液透析等常规治疗基础上加用阿托伐他汀钙片治疗3月.观察治疗前后两组患者白介素 -1(IL -1)、白介素 -6(IL -6)的变化.结果:两组治疗3月后 ,治疗组血浆白介素 -1(IL -1)、白介素 -6(IL-6 )水平较前下降 ,有统计学差异(P<0 .05 ) ,而对照组治疗前后变化不明显.结论:阿托伐他汀钙片不仅可以改善血液透析患者的血脂紊乱 ,而且可降低血液透析患者的微炎症状态 ,值得临床推广.“,”Objective :To observe the Atorvastatin Calcium Tablets on maintenance hemodialysis (M HD) patients with micro inflammatory state factor IL -1、IL -6 .Methods :54 cases of chronic renal failure maintenance hemodialysis patients were randomly divided into the control group and the treatment group of 27 cases .Control group was treated with lower blood pressure ,anemia correction ,correction of acidosis ,correction of renal osteodystrophy and maintenance hemodialysis and other conventional treatment ,the treatment group in lower blood pressure ,anemia ,correction of acidosis ,correction of renal osteodystrophy and maintain hemodialysis of conventional therapy plus atorvastatin cutting atorvastatin calcium tab-lets for 3 months .To observe the changes of IL -1、IL -6 in two groups of patients before and after treatment .Results :after treatment in 3months ,the level of IL -1、IL -6 in the treatment group was decreased ,and there were significant difference (P<0 .05) ,but the change of the control group was not obvious .Conclusion :atorvastatin atorvastatin calcium can not only improve blood lipid disorders in hemodialysis patients , and can reduce the microinflammation state in hemodialysis patients ,is worth the clinical promotion