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目的评价血液灌流(HP)治疗急性重度有机磷农药中毒的疗效。方法选择2005—2009年在昆明市延安医院住院的急性重度有机磷中毒患者80例,经血液灌流治疗40例,未经血液灌流治疗40例,对照分析两组患者临床治疗效果。结果与非血液灌流组比较,HP组与非HP组相比较,昏迷时间、住院时间明显缩短,死亡率明显下降,经统计学检验有显著性差异(P<0.01),治愈率明显提高(P<0.01),两组有机磷中毒患者人院24h后血CHE水平、阿托品总用量、呼吸机使用时间、CHE恢复至50%的时间比较差异均有统计学意义(P<0.05),血液灌流不良反应轻微。结论对急性重度有机磷农药中毒患者在综合治疗基础上加用血液灌流,治疗效果显著,值得推广应用。
Objective To evaluate the efficacy of hemoperfusion (HP) in the treatment of acute severe organophosphorus pesticide poisoning. Methods Eighty patients with acute severe organophosphate poisoning who were hospitalized in Yan’an Hospital of Kunming from 2005 to 2009 were selected. Forty cases were treated by hemoperfusion and 40 cases were treated by hemoperfusion. The clinical effects of two groups were compared. Results Compared with non-hemoperfusion group, the coma time and hospitalization time were significantly shortened and the mortality rate was significantly decreased in HP group compared with non-HP group (P <0.01), and the cure rate was significantly increased (P <0.01). There was significant difference in CHE level, total atropine use time, ventilator use time and CHE recovery time to 50% after hospitalization for 24h in two groups of patients with organophosphate poisoning (P <0.05) Minor reactions. Conclusion Acute severe organophosphorus pesticide poisoning in patients with combined treatment based on the use of hemoperfusion, the treatment effect is significant, it is worth promoting the application.