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[目的]研究探讨非肥胖的2型糖尿病患者危险因素,并进行分析,以指导临床治疗。[方法]收集某院2008年1月~2010年10月健康体检及门诊、住院病人的临床资料,收集67例非肥胖的2型糖尿病患者(观察组),及80例体检健康者(对照组),比较两组FPG、PBG2h、FINS、HbA1c、hs-CRP、SBP、DBP、TG、TC及LDL-C、HDL-C等指标,分析其在非肥胖2型糖尿病患者中的分布情况,讨论非肥胖的2型糖尿病患者的危险因素等。[结果]观察组除HDL-C明显低于对照组外,其他观察指标如FPG、PBG2h、FINS、HbA1c、hs-CRP、SBP、DBP、TG、TC及LDL-C等指标明显高于对照组,差异有统计学意义(P﹤0.05)。[结论]高血糖、高血压、血脂异常及炎症状态是影响非肥胖型2型糖尿病患者的危险因素,临床上应该引起高度重视。
[Objective] To study the risk factors of non-obese type 2 diabetes and to analyze them to guide the clinical treatment. [Methods] The clinical data of healthy physical examination, outpatients and inpatients from January 2008 to October 2010 in a hospital were collected. Sixty-seven non-obese type 2 diabetic patients (observation group) and 80 healthy controls (control group ), The distribution of FPG, PBG2h, FINS, HbA1c, hs-CRP, SBP, DBP, TG, TC, LDL-C and HDL-C in two groups were compared and analyzed in non-obese type 2 diabetes mellitus Non-obese patients with type 2 diabetes risk factors. [Results] The other indexes such as FPG, PBG2h, FINS, HbA1c, hs-CRP, SBP, DBP, TG, TC and LDL-C in the observation group were significantly higher than those in the control group except HDL- , The difference was statistically significant (P <0.05). [Conclusion] Hyperglycemia, hypertension, dyslipidemia and inflammatory state are the risk factors affecting non-obese type 2 diabetes patients, which should be paid more attention in clinic.