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非酒精性脂肪性肝病是一种遗传-环境-代谢应激相关性疾病。其发病机制尚未完全明确。其中肝细胞线粒体功能障碍对于非酒精性脂肪性肝病的发生发展起着关键作用。线粒体是肝细胞代谢所需能量的主要来源,其功能受损主要表现为线粒体膜流动性的下降,从而影响肝脏脂肪代谢,加重脂肪沉积,表现为非酒精性脂肪肝,进一步可发展为脂肪性肝炎甚至肝硬化。因此,有必要阐明线粒体膜流动性与非酒精性脂肪性肝病的关系,从而指导新的治疗方向。
Non-alcoholic fatty liver disease is a genetic - environmental - metabolic stress-related diseases. Its pathogenesis is not yet completely clear. Among them, the mitochondrial dysfunction of hepatocytes plays a key role in the occurrence and development of nonalcoholic fatty liver disease. Mitochondria is the main source of energy required for hepatocyte metabolism, and its impaired function is mainly manifested as a decrease in the fluidity of the mitochondrial membrane, thereby affecting hepatic fat metabolism, aggravating fat deposition, presenting as non-alcoholic fatty liver, and further developing into fatty Hepatitis or even cirrhosis. Therefore, it is necessary to elucidate the relationship between mitochondrial membrane fluidity and non-alcoholic fatty liver disease, thus guiding the new treatment direction.